Cancer stem cells and their relation to tumor biology Biology Diagrams The cell-cycle state of stem cells determines cell fate propensity. Cell 155 , 135-147 (2013). Article CAS PubMed PubMed Central Google Scholar
The core cell cycle machinery operating in the cell nucleus orchestrates cell division. The key components of this machinery are proteins called cyclins that bind, activate and provide substrate specificity to their associated catalytic partners, the cyclin-dependent kinases (CDKs) 1-4.Cell cycle progression can be divided into four phases: gap 1 (G1), DNA synthesis (S), gap 2 (G2) and The duration of the cell cycle varies from one cell type to another. Most human cells complete the cycle in about 24 hours. Fast-growing cells, like those in the lining of the intestine, may complete it in just 9 or 10 hours, while liver cells take more than a year and neuronal cells take many years. The cell cycle and cancer
The cell cycle in stem cell proliferation, pluripotency and ... Biology Diagrams
Cell cycle regulation depends on phase-specific transcriptions of cell cycle genes. The alterations of cell cycle genes can predispose normal cells to have a cancerous phenotype. Indeed, several mechanisms underlying the deregulation of the cell cycle have been identified in different types of cancer.
Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor heterogeneity.
TET1 regulates stem cell properties and cell cycle of Cancer stem cells ... Biology Diagrams
The role of cancer stem cells in metastasis, recurrence, and resistance to conventional therapies is significant. Addressing these cells could potentially decrease cancer reoccurrences and mortality rates. TET1, a crucial gene involved in stem cell self-renewal and potency, may also play a part in cancer stem cells, which warrants further research. In addition to the properties of self-renewal and multipotency, cancer stem cells share the characteristics of their distinct cell cycle status with somatic stem cells. Cancer stem cells (CSCs) are maintained in a quiescent state with this characteristic conferring resistance to anticancer therapies that target dividing cells. Elucidation of
